Early screening for kidney function in dogs (SDMA) is a key test for detecting kidney damage caused by aging or disease at an early stage. We’ve compiled essential questions and answers that pet owners should know.




High SDMA Levels Require an Immediate Veterinary Visit
If SDMA levels fall outside the normal range, it may indicate a decline in kidney function. However, SDMA can also be elevated due to non-renal factors such as dehydration, so it’s important to consult with your veterinarian for retesting and additional diagnostics to determine the underlying cause.

| Item | SDMA test | Creatinine test |
|---|---|---|
| Point of early detection | Rises when about 40% of kidney function is lost | Rises when about 75% of kidney function is lost |
| Sensitivity for early detection | High (rises earlier) | Low (rises in later stages) |
| Recommended use | Useful for early screening and routine monitoring | Basic marker for assessing kidney function |
| Cautions in interpretation | May reflect extra-renal causes such as dehydration or give false positives; retesting needed | May read low when muscle mass is reduced |
SDMA rises earlier than creatinine, making it useful for early detection of kidney disease, but false positives can occur due to extra-renal factors such as dehydration or assay variability, so retesting and trend monitoring are needed.


A veterinarian who majored in veterinary medicine at Khon Kaen University, Thailand, and completed the IVSA program at North Carolina State University in the United States. Drawing on clinical experience at animal hospitals, he works in the pet healthcare field and is dedicated to building a digital care environment that connects pet parents with veterinarians.
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[1] Plumb's Veterinary Drug Handbook, 9th Edition, 2022
[2] The Cat, Clinical Medicine and Management, 2nd Edition, 2021
[3] Veterinary Clinical Pathology, 5th Edition, 2020