Early screening for kidney function in cats using SDMA is a key test for detecting kidney disease in older cats at an early stage. We’ve summarized the essential information that pet owners should know.




| Item | SDMA | Creatinine |
|---|---|---|
| Detection timing | Reported to rise earlier than creatinine | Rises after kidney function has significantly declined |
| GFR reflection | Correlates well with GFR (use caution with sole judgment) | Correlates with GFR but reflects it relatively late |
| Potential for early detection | Relatively early | Relatively late |
| Support for decision-making | Useful when combined with creatinine and urinalysis | Limited when used alone |
SDMA may reflect a decline in kidney function earlier than creatinine, but it can also rise due to non-renal factors, so it is recommended to interpret it together with creatinine and urinalysis.
Signs that require an immediate vet visit
If your cat suddenly starts drinking excessive amounts of water, using the litter box more frequently, or experiencing a sharp decline in appetite, you should take them to the vet immediately. These could be early signs of kidney disease.



A veterinarian who majored in veterinary medicine at Khon Kaen University, Thailand, and completed the IVSA program at North Carolina State University in the United States. Drawing on clinical experience at animal hospitals, he works in the pet healthcare field and is dedicated to building a digital care environment that connects pet parents with veterinarians.
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[1] Langston, C.E. et al. (2023) Small Animal Critical Care Medicine, 3rd Edition. Elsevier.
[2] The Cat, Clinical Medicine and Management, 2nd Edition (2022). Elsevier.
[3] Veterinary Workbook of Small Animal Clinical Cases (2021). Wiley-Blackwell.