Canine scabies is a parasitic infection caused by Sarcoptes scabiei mites burrowing and reproducing within the skin, leading to intense itching. Early diagnosis and precise deworming treatment are essential.


Signs Requiring Immediate Veterinary Visit
If you notice any of the following signs, please visit a veterinary clinic within 24 hours. If left untreated, scabies can lead to secondary bacterial infections, prolonging recovery time and potentially spreading to you. - Itching persists for more than 48 hours and worsens over time - Pus or a foul odor is present on the skin - A rash spreads rapidly across the body - Red rashes appear on your arms or abdomen (possible zoonotic transmission) - Loss of appetite and lethargy are also present
| Item | Selamectin (topical) | Isoxazoline (oral) | Ivermectin (injection/oral) |
|---|---|---|---|
| Administration method | Applied to the back of the neck | Oral (treat form) | Injection or oral |
| Dosing interval | 2–3 times at 2-week intervals | Once or once monthly | Determined by veterinarian |
| Onset of effect | 24–48 hours | 8–24 hours | 24–48 hours |
| Ease of use for owners | True | True | False |
| Safety in Collies/Shetlands | Safe | Safe | Caution needed |
The actual drug type, dose, and interval are decided by the veterinarian based on body weight and health status.


Breed and Constitution-Specific Precautions
Herding breeds such as Collies, Shetland Sheepdogs, Australian Shepherds, and Border Collies may carry a defect in the multidrug resistance 1 (MDR1) gene. This genetic defect can cause severe side effects, such as tremors and coma, when these dogs are treated with certain dewormers like ivermectin and milbemycin. For these breeds, it is advisable to undergo genetic testing before selecting a dewormer or to use safer alternatives from the isoxazoline class or selamectin. You may also find our guide on canine MDR1 gene testing helpful.

A veterinarian who majored in veterinary medicine at Khon Kaen University, Thailand, and completed the IVSA program at North Carolina State University in the United States. Drawing on clinical experience at animal hospitals, he works in the pet healthcare field and is dedicated to building a digital care environment that connects pet parents with veterinarians.
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[1] BSAVA Manual of Canine and Feline Dermatology, 4th Edition, Chapter on Ectoparasitic Diseases
[2] Principles and Practices of Canine and Feline Clinical Parasitic Diseases, Chapter 7
[3] Shoorijeh, S.J., Ghasrodashti, A.R., Tamadon, A. et al. (2008). Seasonal frequency of ectoparasite infestation in dogs from Shiraz, Southern Iran. Turkish Journal of Veterinary and Animal Sciences 32(4): 309-313
[4] Current Research in Parasitology & Vector-Borne Diseases 1: 100035 (2021)